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These immune-mediated events were compounded by intolerable gastrointestinal side effects, including nausea in 59% and vomiting in 37% of participants, along with reports of acute pancreatitis, culminating in a dropout rate of 26–34% in Phase 3 trials [65]
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Cohort follow-up began at drug initiation, and cases occurring shortly after initiation may not be causally related, although this may be nondifferential given that the active comparator is also a second-line agent
